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A Review of Numerical and Experimental Compensation Techniques for Skull-Induced Phase Aberrations in Transcranial Focused Ultrasound
10/12/2013

A Review of Numerical and Experimental Compensation Techniques for Skull-Induced Phase Aberrations in Transcranial Focused Ultrasound

Adamos Kyriakou, Esra Neufeld, Beat Werner, Margarethus Paulides, Gabor Szekely, and Niels Kuster, International Journal of Hyperthermia, Volume 30, Issue 1, pp. 36-46, February 2014, online December 10, 2013

Transcranial focused ultrasound (tcFUS) is an attractive noninvasive modality for neurosurgical interventions. The presence of the skull, however, compromises the efficiency of tcFUS therapy, as its heterogeneous nature and acoustic characteristics induce significant phase aberrations and energy attenuation, especially at the higher acoustic frequencies employed in tcFUS thermal therapy. These aberrations may distort and shift the acoustic focus as well as induce heating at the patient’s scalp and skull bone.

Phased array transducers feature hundreds of elements that can be driven individually, each with its own phase and amplitude. This feature allows for compensation of skull-induced aberrations by calculation and application of appropriate phase and amplitude corrections. In this paper, we illustrate the importance of precise refocusing and provide a comprehensive review of the wide variety of numerical and experimental techniques that have been used to estimate these corrections.

The scientific impact of this study can be summarized as:

  • Overview of the current state of tcFUS interventions used in medical centers around the world for treatment of various neuropathic conditions, recently completed and ongoing clinical trials, and reported complications.
  • Comprehensive overview of over 20 years of in vitro, in vivo, and in silico approaches to research in the field of skull-induced aberration corrections.
  • Critical assessment of different tcFUS techniques, their strengths and shortcomings, as well as the necessary provisions required for the individual techniques to be applied in the clinical environment.
PAPERS

26/11/2013

Contact
balzano@itis-usa.org

 

Experimental and Numerical Assessment of Low-Frequency Current Distributions from UMTS and GSM Mobile Phones

Marie-Christine Gosselin, Sven Kühn, and Niels Kuster, Physics in Medicine and Biology, Volume 58, Issue 23, pp. 8339–8357, December 2013, online November 11, 2013

 
PAPERS

14/08/2013

Contact
balzano@itis-usa.org

 

A Novel Medical Image Data-Based Multi-Physics Simulation Platform for Computational Life Sciences

Esra Neufeld, Dominik Szczerba, Nicolas Chavannes, and Niels Kuster, Interface Focus, Volume 3, Issue 3, April 2013, online February 21, 2013

 
PAPERS

14/05/2013

Contact
balzano@itis-usa.org

 

Simulation Techniques in Hyperthermia Treatment Planning

Margarethus Paulides, Paul Stauffer, Esra Neufeld, Paolo Maccarini, Adamos Kyriakou, Richard Canters, Chris Diederich, Jurriaan Bakker, and Gerard van Rhoon, International Journal of Hyperthermia, Volume 29, Issue 4, pp.346–357, June 2013, online May 14, 2013

 
PAPERS

29/04/2013

Contact
balzano@itis-usa.org

 

Assessing Human Exposure to Electromagnetic Fields From Wireless Power Transmission Systems

Andreas Christ, Mark Douglas, Jagadish Nadakuduti, and Niels Kuster, Proceedings of the IEEE , Volume 101, Issue 6, pp. 1482-1493, June 2013, online March 13, 2013

 
PAPERS

19/04/2013

Contact
balzano@itis-usa.org

 

Antenna Design and Tissue Parameters Considerations for Improved Modelling of Microwave Ablation in the Liver

Andreas Karampatzakis, Sven Kühn, George Tsanidis, Esra Neufeld, Theodoros Samaras, and Niels Kuster, Physics in Medicine and Biology, Volume 58, Issue 10, pp. 3191–3206, May 2013, online April 19, 2013

 
 
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