Esra Neufeld, Dominik Szczerba, Nicolas Chavannes, and Niels Kuster, Interface Focus, Volume 3, Issue 3, April 2013, online February 21, 2013
Modeling complex biological systems in computational life sciences requires specialized tools that can perform medical-image-data-based simulations and can handle complex and realistic anatomical models. The required solvers must be optimized for modeling living tissue and high-performance-computing-enabled to cope with the frequently large numerical problems. A multi-physics platform that satisfies these requirements has been implemented and used to investigate a wide variety of relevant applications, some of which are presented in this paper. The simulation platform consists of detailed, parameterized anatomical models, a segmentation and meshing tool, a wide range of solvers and optimizers, a framework for the rapid development of specialized and parallelized finite element method solvers, a toolkit-based visualization engine, a PYTHON scripting interface for customized applications, a coupling framework, and more.
The scientific impact of this study can be summarized as: