NEWS
22/04/2015
Anatomical Model of the Human Head and Neck

MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck

Maria Iacono, Esra Neufeld, Esther Akinnagbe, Kelsey Bower, Johanna Wolf, Ioannis Oikonomidis, Deepika Sharma, Bryn Lloyd, Bertram Wilm, Michael Wyss, Klaas Pruessmann, Andras Jakab, Nikos Makris, Ethan Cohen, Niels Kuster, Wolfgang Kainz, and Leonardo Angelone, PLoS ONE, Volume 10, Issue 4, online April 22, 2015

Computational modelling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck. The model was obtained by integrating three different magnetic resonance imaging (MRI) modalities, the parameters of which were tailored to enhance the signals of specific tissues: i) structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii) magnetic resonance angiography (MRA) data to image the vasculature, and iii) diffusion tensor imaging (DTI) to obtain information on anisotropy and fibre orientation. The unique multimodal high-resolution approach allowed resolving 150 structures, including several distinct muscles, bones and skull layers, arteries and veins, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which transcranial alternating current stimulation was modelled.

The scientific and technical impact of the study can be summarized as:

  • Creating and making available a detailed, high-resolution head model distinguishing a large number of tissues
  • Creating high element-quality, topologically conforming, non-intersecting surfaces suitable for structured and unstructured discretization techniques
  • Integrating image-based information to inform on inhomogeneous and anisotropic property distributions
  • Demonstrating the suitability of the head model for a large range of numerical simulation techniques
 
 
 
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PAPERS

17/04/2015

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balzano@itis-usa.org

 

Compliance Testing Methodology for Wireless Power Transfer Systems

Jagadish Nadakuduti, Mark Douglas, Lin Lu, Andreas Christ, Paul Guckian, and Niels Kuster, IEEE Transactions on Power Electronics, Volume PP, Issue 99, online February 19, 2015

 
PAPERS

19/02/2015

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balzano@itis-usa.org

 

Inter-Individual and Intra-Individual Variation of the Effects of Pulsed RF EMF Exposure on the Human Sleep EEG

Caroline Lustenberger, Manuel Murbach, Laura Tüshaus, Flavia Wehrle, Niels Kuster, Peter Achermann, and Reto Huber, Bioelectromagnetics, Volume 36, Issue 3, pp. 169–177, April 2015, online February 17, 2015

 
PAPERS

16/02/2015

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balzano@itis-usa.org

 

The Discrepancy between Maximum In Vitro Exposure Levels and Realistic Conservative Exposure Levels of Mobile Phones Operating at 900/1800 MHz

Gernot Schmid and Niels Kuster, Bioelectromagnetics, Volume 36, Issue 2, pp. 133–148, February 2015, online January 30, 2015

 
PAPERS

21/01/2015

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balzano@itis-usa.org

 

Human Exposure from Pulsed Magnetic Field Therapy Mats: A Numerical Case Study with Three Commercial Products

Valerio De Santis, Mark Douglas, Jagadish Nadakuduti, Stefan Benkler, Xi Lin Chen, and Niels Kuster, Bioelectromagnetics, Volume 36, Issue 2, pp. 149–161, February 2015, online January 16, 2015

 
PAPERS

11/12/2014

Contact
balzano@itis-usa.org

 

Genetic Analysis of Circadian Responses to Low Frequency Electromagnetic Fields in Drosophila melanogaster

Giorgio Fedele, Mathew Edwards, Supriya Bhutani, John Hares, Manuel Murbach, Edward Green, Stephane Dissel, Michael Hastings, Ezio Rosato, and Charalambos Kyriacou, PLoS Genetics, Volume 10, Issue 12, online December 4, 2014

 
PAPERS

03/11/2014

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balzano@itis-usa.org

 

Quantification of RF-Exposure of the Fetus Using Anatomical CAD-Models in Three Different Gestational Stages

Eugenia Cabot, Andreas Christ, Barbara Bühlmann, Marcel Zefferer, Nicolas Chavannes, Jurriaan F. Bakker, Gerard C. van Rhoon, and Niels Kuster, Health Physics, Volume 107, Issue 5, pp. 369381, online November 2014

 
PAPERS

29/09/2014

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balzano@itis-usa.org

 

Dosimetric Study of Fetal Exposure to Uniform Magnetic Fields at 50 Hz

Ilaria Liorni, Marta Parazzini, Serena Fiocchi, Mark Douglas, Myles Capstick, Marie-Christine Gosselin, Niels Kuster, and Paolo Ravazzani, Bioelectromagnetics, Volume 35, Issue 8, pp. 580597, online September 29, 2014

 
PAPERS

21/08/2014

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balzano@itis-usa.org

 

Development of a New Generation of High-Resolution Anatomical Models for Medical Device Evaluation: The Virtual Population 3.0

Marie-Christine Gosselin, Esra Neufeld, Heidi Moser, Eveline Huber, Silvia Farcito, Livia Gerber, Maria Jedensjö, Isabel Hilber, Fabienne Di Gennaro, Bryn Lloyd, Emilio Cherubini, Dominik Szczerba, Wolfgang Kainz, and Niels Kuster, Physics in Medicine and Biology, Volume 59, Issue 18, pp. 5287–5303, online August 21, 2014

 
PAPERS

03/07/2014

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balzano@itis-usa.org

 

Influence of Non Ionizing Radiation of Base Stations on the Activity of Redox Proteins in Bovines

Michael Hässig, Marietta Wullschleger, Hanspeter Naegeli, Jaqueline Kupper, Bernhard Spiess, Niels Kuster, Myles Capstick, and Manuel Murbach, BMC Veterinary Research, Volume 10, Issue 136, online June 19, 2014

 
PAPERS

12/03/2014

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balzano@itis-usa.org

 

Human Exposure to Close-Range Resonant Wireless Power Transfer Systems as a Function of Design Parameters

Xi Lin Chen, Aghuinyue Umenei, David Baarman, Nicolas Chavannes, Valerio De Santis, Juan Mosig, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume PP, Issue 99, pp. 1-8, online March 12, 2014

 
PAPERS

01/03/2014

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balzano@itis-usa.org

 

Dosimetric Assessment of Two-Layer Cell Culture Configurations for Fertility Research at 1950 MHz

Yijian Gong, Manuel Murbach, Teruo Onishi, Myles Capstick, Toshio Nojima, and Niels Kuster, IEICE Transactions on Communications, Volume E97-B, Issue 3, pp. 631-637, online March 1, 2014

 
PAPERS

16/02/2014

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balzano@itis-usa.org

 

Modeling of EEG Electrode Artifacts and Thermal Ripples in Human Radiofrequency Exposure Studies

Manuel Murbach, Esra Neufeld, Maria Christopoulou, Peter Achermann, and Niels Kuster, Bioelectromagnetics,Volume 35, Issue 4, pp. 273-283, online February 13, 2014.

 
PAPERS

10/12/2013

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balzano@itis-usa.org

 

A Review of Numerical and Experimental Compensation Techniques for Skull-Induced Phase Aberrations in Transcranial Focused Ultrasound

Adamos Kyriakou, Esra Neufeld, Beat Werner, Margarethus Paulides, Gabor Szekely, and Niels Kuster, International Journal of Hyperthermia, Volume 30, Issue 1, pp. 36-46, February 2014, online December 10, 2013

 
PAPERS

26/11/2013

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balzano@itis-usa.org

 

Experimental and Numerical Assessment of Low-Frequency Current Distributions from UMTS and GSM Mobile Phones

Marie-Christine Gosselin, Sven Kühn, and Niels Kuster, Physics in Medicine and Biology, Volume 58, Issue 23, pp. 8339–8357, December 2013, online November 11, 2013

 
PAPERS

14/08/2013

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balzano@itis-usa.org

 

A Novel Medical Image Data-Based Multi-Physics Simulation Platform for Computational Life Sciences

Esra Neufeld, Dominik Szczerba, Nicolas Chavannes, and Niels Kuster, Interface Focus, Volume 3, Issue 3, April 2013, online February 21, 2013

 
PAPERS

14/05/2013

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balzano@itis-usa.org

 

Simulation Techniques in Hyperthermia Treatment Planning

Margarethus Paulides, Paul Stauffer, Esra Neufeld, Paolo Maccarini, Adamos Kyriakou, Richard Canters, Chris Diederich, Jurriaan Bakker, and Gerard van Rhoon, International Journal of Hyperthermia, Volume 29, Issue 4, pp.346–357, June 2013, online May 14, 2013

 
PAPERS

29/04/2013

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balzano@itis-usa.org

 

Assessing Human Exposure to Electromagnetic Fields From Wireless Power Transmission Systems

Andreas Christ, Mark Douglas, Jagadish Nadakuduti, and Niels Kuster, Proceedings of the IEEE , Volume 101, Issue 6, pp. 1482-1493, June 2013, online March 13, 2013

 
PAPERS

19/04/2013

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balzano@itis-usa.org

 

Antenna Design and Tissue Parameters Considerations for Improved Modelling of Microwave Ablation in the Liver

Andreas Karampatzakis, Sven Kühn, George Tsanidis, Esra Neufeld, Theodoros Samaras, and Niels Kuster, Physics in Medicine and Biology, Volume 58, Issue 10, pp. 3191–3206, May 2013, online April 19, 2013

 
PAPERS

17/04/2013

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balzano@itis-usa.org

 

CEM43°C Thermal Dose Thresholds: A Potential Guide for Magnetic Resonance Radiofrequency Exposure Levels?

Gerard C. van Rhoon, Theodoros Samaras, Pavel S. Yarmolenko, Mark W. Dewhirst, Esra Neufeld, and Niels Kuster,European Radiology, Volume 23, Issue 8, pp. 2215-2227, August 2013, online April, 2013

 
PAPERS

26/03/2013

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balzano@itis-usa.org

 

Analysis of Mobile Phone Design Features Affecting Radio-frequency Power Absorbed in a Human Head Phantom

Sven Kühn, Michael Kelsh, Niels Kuster, Asher Sheppard, and Mona Shum, Bioelectromagnetics, Volume 34, Issue 6,pp. 479–488, September 2013, online March 26, 2013

 
PAPERS

15/03/2013

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balzano@itis-usa.org

 

Stimulation of the Brain with Radiofrequency Electromagnetic Field Pulses Affects Sleep-Dependent Performance Improvement

Caroline Lustenberger, Manuel Murbach, Roland Dürr, Marc R. Schmid, Niels Kuster, Peter Achermann, and Reto Huber, Brain Stimulation, Volume 6, Issue 5, pp. 805-811, September 2013, online February 26, 2013

 
PAPERS

11/03/2013

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balzano@itis-usa.org

 

Whole-Body and Local RF Absorption in Human Models as a Function of Anatomy and Position within 1.5T MR Body Coil

Manuel Murbach, Esra Neufeld, Wolfgang Kainz, Klaas P. Pruessmann, and Niels Kuster, Magnetic Resonance in Medicine, Volume 71, Issue 2, pp. 839-845, February 2014, online February 25, 2013

 
PAPERS

25/02/2013

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balzano@itis-usa.org

 

No Increased Sensitivity in Brain Activity of Adolescents Exposed to Mobile Phone-Like Emissions

Sarah P. Loughran, Dominik Benz, Marc Schmid, Manuel Murbach, Niels Kuster, and Peter Achermann, Clinical Neurophysiology, Volume 124, Issue 7, pp. 1303-1308, July 2013, online February 20, 2013

 
PAPERS

19/02/2013

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balzano@itis-usa.org

 

Thermal Tissue Damage Model Analyzed for Different Whole-Body SAR and Scan Durations for Standard MR Body Coils

Manuel Murbach, Esra Neufeld, Myles Capstick, Wolfgang Kainz, David O. Brunner, Theodoros Samaras, Klaas P. Pruessmann, and Niels Kuster, Magnetic Resonance in Medicine, Volume 71, Issue 1, pp. 421-431, January 2014, online February 14, 2013

 
PAPERS

18/02/2013

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balzano@itis-usa.org

 

Analysis of Human Brain Exposure to Low-Frequency Magnetic Fields: A Numerical Assessment of Spatially Averaged Electric Fields and Exposure Limits

Xi Lin Chen, Stefan Benkler, Nicholas Chavannes, Valerio De Santis, Jurriaan Bakker, Gerard van Rhoon, Juan Mosig, and Niels Kuster, Bioelectromagnetics, Volume 34, Issue 5, pp. 375-384, July 2013, February 12, 2013

 
PAPERS

31/01/2013

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balzano@itis-usa.org

 

Influence of GSM Signals on Human Peripheral Lymphocytes: Study of Genotoxicity

Petra Waldmann, Susanne Bohnenberger, Rüdiger Greinert, Beate Hermann-Then, Anja Heselich, Stefanie J. Klug, Jochem Koenig, Kathrin Kuhr, Niels Kuster, Mandy Merker, Manuel Murbach, Dieter Pollet, Walter Schadenboeck, Ulrike Scheidemann-Wesp, Britt Schwab, Beate Volkmer, Veronika Weyer, and Maria Blettner, Radiation Research, Volume 179, Issue 4, pp. 243-253, April 2013, online January 14, 2013

 
PAPERS

28/01/2013

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balzano@itis-usa.org

 

Cell Type-Dependent Induction of DNA Damage by 1800 MHz Radiofrequency Electromagnetic Fields Does Not Result in Significant Cellular Dysfunctions

Shanshan Xu, Guangdi Chen, Chunjing Chen, Chuan Sun, Danying Zhang, Manuel Murbach, Niels Kuster, Qunli Zeng, and Zhengping Xu, PLoS ONE, Volume 8, Issue 1, online ahead of print January 23, 2013

 
OTHER NEWS

18/01/2013

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balzano@itis-usa.org

 

3rd Board Meeting

IT'IS USA held its third board meeting on January 18, 2013.

 
OTHER NEWS

18/01/2013

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balzano@itis-usa.org

 

IT'IS USA joins the Medical Device Innovation Consortium

IT'IS USA has become a member of the Medical Device Innovation Consortium (MDIC).

 
PAPERS

15/11/2012

Contact
balzano@itis-usa.org

 

Field Evaluation of the Human Exposure from Multi-Band, Multi-System Mobile Phones

Sven Kühn, and Niels Kuster, IEEE Transactions Electromagnetics Compatibility, Volume 55, Issue 2, pp. 275-287, April 2013, online November 15, 2012

 
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